diff --git a/app/javascript/mastodon/features/navigation_panel/redesign/header.tsx b/app/javascript/mastodon/features/navigation_panel/redesign/header.tsx
index bf0b1d6b90f..09ea3fb424c 100644
--- a/app/javascript/mastodon/features/navigation_panel/redesign/header.tsx
+++ b/app/javascript/mastodon/features/navigation_panel/redesign/header.tsx
@@ -6,6 +6,8 @@ import { Link } from 'react-router-dom';
 import { IconLogo } from '@/mastodon/components/logo';
 import { customAppIcon, domain, title } from '@/mastodon/initial_state';
 
+import { getNavigationSkipLinkId } from '../../ui/components/skip_links';
+
 import classes from './header.module.scss';
 
 export const NavigationHeader: React.FC<{
@@ -24,7 +26,11 @@ export const LogoLockup: React.FC<{
   className?: string;
 }> = ({ siteName, className }) => {
   return (
-    <Link to='/' className={classNames(classes.siteNameLink, className)}>
+    <Link
+      to='/'
+      className={classNames(classes.siteNameLink, className)}
+      id={getNavigationSkipLinkId()}
+    >
       {customAppIcon && (
         <img src={customAppIcon} alt='' className={classes.appIcon} />
       )}
diff --git a/app/javascript/mastodon/features/ui/components/columns_area/redesign_multicol.module.scss b/app/javascript/mastodon/features/ui/components/columns_area/redesign_multicol.module.scss
index a23e9d53b87..170e85ace1f 100644
--- a/app/javascript/mastodon/features/ui/components/columns_area/redesign_multicol.module.scss
+++ b/app/javascript/mastodon/features/ui/components/columns_area/redesign_multicol.module.scss
@@ -11,6 +11,16 @@
   gap: var(--multi-column-gap);
   padding-inline-end: var(--multi-column-gap);
   overflow-x: auto;
+  scroll-padding-inline-start: var(--multi-column-navigation-width);
+
+  &:focus-visible {
+    // Scrollable elements are made focusable by some browsers, this adds
+    // a visible outline in this case. Using `border` instead of `outline`
+    // causes a light layout jump shift on focus, but an outline would be
+    // rendered below the navbar and columns and didn't look right.
+    border: var(--outline-focus-default);
+    border-radius: var(--radius-2);
+  }
 }
 
 .navigationWrapper {
diff --git a/app/javascript/mastodon/features/ui/components/skip_links/index.tsx b/app/javascript/mastodon/features/ui/components/skip_links/index.tsx
index e5a74ba992b..f297f52bb86 100644
--- a/app/javascript/mastodon/features/ui/components/skip_links/index.tsx
+++ b/app/javascript/mastodon/features/ui/components/skip_links/index.tsx
@@ -2,15 +2,16 @@ import { useCallback, useId } from 'react';
 
 import { useIntl } from 'react-intl';
 
+import { isRedesignEnabled } from '@/mastodon/utils/environment';
 import { useAppSelector } from 'mastodon/store';
 
 import classes from './skip_links.module.scss';
 
 export const getNavigationSkipLinkId = () => 'skip-link-target-nav';
-export const getColumnSkipLinkId = (index: number) =>
-  `skip-link-target-content-${index}`;
+export const getColumnSkipLinkId = (index: number | null) =>
+  `skip-link-target-content-${index ?? ''}`;
 
-export const SkipLinks: React.FC<{
+const LegacySkipLinks: React.FC<{
   multiColumn: boolean;
   onFocusGettingStartedColumn: () => void;
 }> = ({ multiColumn, onFocusGettingStartedColumn }) => {
@@ -54,6 +55,23 @@ export const SkipLinks: React.FC<{
   );
 };
 
+const RedesignSkipLinks: React.FC = () => {
+  const intl = useIntl();
+
+  return (
+    <div className={classes.list}>
+      <div className={classes.listItem}>
+        <SkipLink target={getColumnSkipLinkId(1)} hotkey='2'>
+          {intl.formatMessage({
+            id: 'skip_links.skip_to_content',
+            defaultMessage: 'Skip to main content',
+          })}
+        </SkipLink>
+      </div>
+    </div>
+  );
+};
+
 const SkipLink: React.FC<{
   children: string;
   target: string;
@@ -82,3 +100,7 @@ const SkipLink: React.FC<{
     </>
   );
 };
+
+export const SkipLinks = isRedesignEnabled()
+  ? RedesignSkipLinks
+  : LegacySkipLinks;
diff --git a/app/javascript/mastodon/features/ui/components/skip_links/skip_links.module.scss b/app/javascript/mastodon/features/ui/components/skip_links/skip_links.module.scss
index ad206dfecc5..580231d468a 100644
--- a/app/javascript/mastodon/features/ui/components/skip_links/skip_links.module.scss
+++ b/app/javascript/mastodon/features/ui/components/skip_links/skip_links.module.scss
@@ -1,6 +1,6 @@
 .list {
   position: fixed;
-  z-index: 100;
+  z-index: 200;
   margin: 10px;
   padding: 10px 16px;
   border-radius: 10px;
diff --git a/app/javascript/mastodon/features/ui/index.jsx b/app/javascript/mastodon/features/ui/index.jsx
index d2eb635f634..75f84049128 100644
--- a/app/javascript/mastodon/features/ui/index.jsx
+++ b/app/javascript/mastodon/features/ui/index.jsx
@@ -649,6 +649,7 @@ class UI extends PureComponent {
         <div className={classNames('ui', { 'is-composing': isComposing })} ref={this.setRef}>
           {!minimalShell && (
             <SkipLinks
+              // TODO: Remove these props & related methods when isRedesignEnabled() flag is removed
               multiColumn={layout === 'multi-column'}
               onFocusGettingStartedColumn={this.handleHotkeyGoToStart}
             />
diff --git a/app/javascript/mastodon/features/ui/util/focusUtils.ts b/app/javascript/mastodon/features/ui/util/focusUtils.ts
index 6e6b8e24e09..3d566947dde 100644
--- a/app/javascript/mastodon/features/ui/util/focusUtils.ts
+++ b/app/javascript/mastodon/features/ui/util/focusUtils.ts
@@ -1,3 +1,5 @@
+import { isRedesignEnabled } from '@/mastodon/utils/environment';
+
 import {
   getColumnSkipLinkId,
   getNavigationSkipLinkId,
@@ -45,11 +47,24 @@ function focusColumnTitle(index: number, multiColumn: boolean) {
   }
 }
 
+function focusRedesignColumnTitle(index: number) {
+  const idToFocus =
+    index === 1 ? getNavigationSkipLinkId() : getColumnSkipLinkId(index - 1);
+
+  document.querySelector<HTMLElement>(`#${idToFocus}`)?.focus();
+}
+
 /**
  * Move focus to the column of the passed index (1-based).
  * Focus is placed on the topmost visible item, or the column title.
  */
 export function focusColumn(index = 1) {
+  if (isRedesignEnabled()) {
+    // In the redesign, always focus the column title
+    focusRedesignColumnTitle(index);
+    return;
+  }
+
   // Skip the leftmost drawer in multi-column mode
   const isMultiColumnLayout = !!document.querySelector(
     'body.layout-multiple-columns',