diff --git a/Source/Core/DolphinQt/Config/SettingsWindow.cpp b/Source/Core/DolphinQt/Config/SettingsWindow.cpp
index e80b1fa7ff..283cd3786e 100644
--- a/Source/Core/DolphinQt/Config/SettingsWindow.cpp
+++ b/Source/Core/DolphinQt/Config/SettingsWindow.cpp
@@ -210,3 +210,8 @@ void SettingsWindow::SelectPane(SettingsWindowPaneIndex index)
 {
   ActivatePane(std::to_underlying(index));
 }
+
+void SettingsWindow::closeEvent(QCloseEvent*)
+{
+  Config::Save();
+}
diff --git a/Source/Core/DolphinQt/Config/SettingsWindow.h b/Source/Core/DolphinQt/Config/SettingsWindow.h
index 3874c75ae0..c27d6e919d 100644
--- a/Source/Core/DolphinQt/Config/SettingsWindow.h
+++ b/Source/Core/DolphinQt/Config/SettingsWindow.h
@@ -60,4 +60,6 @@ public:
   explicit SettingsWindow(MainWindow* parent);
 
   void SelectPane(SettingsWindowPaneIndex);
+
+  void closeEvent(QCloseEvent* event) override;
 };
diff --git a/Source/Core/DolphinQt/Settings/GeneralPane.cpp b/Source/Core/DolphinQt/Settings/GeneralPane.cpp
index 802292f688..7561aaa939 100644
--- a/Source/Core/DolphinQt/Settings/GeneralPane.cpp
+++ b/Source/Core/DolphinQt/Settings/GeneralPane.cpp
@@ -16,7 +16,6 @@
 #include "Core/AchievementManager.h"
 #include "Core/Config/MainSettings.h"
 #include "Core/Config/UISettings.h"
-#include "Core/ConfigManager.h"
 #include "Core/Core.h"
 #include "Core/DolphinAnalytics.h"
 #include "Core/System.h"
@@ -117,7 +116,6 @@ void GeneralPane::ConnectLayout()
   connect(m_combobox_speedlimit, &QComboBox::currentIndexChanged, [this] {
     Config::SetBaseOrCurrent(Config::MAIN_EMULATION_SPEED,
                              m_combobox_speedlimit->currentIndex() * 0.1f);
-    Config::Save();
   });
 
   connect(m_combobox_fallback_region, &QComboBox::currentIndexChanged, this,
@@ -339,7 +337,6 @@ void GeneralPane::OnSaveConfig()
 {
   Config::ConfigChangeCallbackGuard config_guard;
 
-  auto& settings = SConfig::GetInstance();
   if (AutoUpdateChecker::SystemSupportsAutoUpdates())
   {
     Settings::Instance().SetAutoUpdateTrack(
@@ -356,8 +353,6 @@ void GeneralPane::OnSaveConfig()
 #endif
   Settings::Instance().SetFallbackRegion(
       UpdateFallbackRegionFromIndex(m_combobox_fallback_region->currentIndex()));
-
-  settings.SaveSettings();
 }
 
 #if defined(USE_ANALYTICS) && USE_ANALYTICS
diff --git a/Source/Core/DolphinQt/Settings/WiiPane.cpp b/Source/Core/DolphinQt/Settings/WiiPane.cpp
index 19d54ca50c..bab5b9b540 100644
--- a/Source/Core/DolphinQt/Settings/WiiPane.cpp
+++ b/Source/Core/DolphinQt/Settings/WiiPane.cpp
@@ -369,7 +369,6 @@ void WiiPane::OnUSBWhitelistAddButton()
   }
   whitelist.emplace(*usb_device);
   Config::SetUSBDeviceWhitelist(whitelist);
-  Config::Save();
   PopulateUSBPassthroughListWidget();
 }