diff --git a/README.md b/README.md
index 0f53c6c..25b1c53 100644
--- a/README.md
+++ b/README.md
@@ -4,6 +4,8 @@ WfcReplay is a command-line Windows utility written in C# that automatically gen
 
 To run this program, the .NET Framework 4.0 or higher must be installed on your computer.
 
+NOTE: Older versions of DeSmuME are incompatible with codes generated by WfcReplay. Use a newer version of DeSmuME based on r5047 or later, or try an alternative patching method.
+
 Usage
 -----
 ```